“Functional MRI of Decision-Making in Substance Abuse and Pathological Gambling”

Principal Investigator: Jody Tanabe, MD, University of Colorado Health Sciences Center
Awarded $172,500 in 2003

Aim: Test hypothesis that defects in ventral medial frontal processing lead to impaired decisions that involve risk.

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Tanabe, J., Thompson, L., Claus, E., Dalwani, M., Hutchison, K., & Banich, M. T. (2007). Prefrontal cortex activity is reduced in gambling and nongambling substance users during decision-making. Human Brain Mapping, 28(12), 1276–86. http://doi.org/10.1002/hbm.20344

Tanabe, J., Tregellas, J. R., Thompson, L., Dalwani, M., Owens, E., Crowley, T., & Banich, M. (2009). Medial orbitofrontal cortex gray matter is reduced in abstinent substance dependent individuals. Biological Psychiatry, 65(2), 160–164. http://doi.org/10.1016/j.biopsych.2008.07.030

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Year: 2003
Type: Project Grants