Do you know of a researcher, educator or a recent publication that has made an impact in the field of gambling disorder research? The National Center for Responsible Gaming (NCRG), the largest private source of funding for peer-reviewed research on disordered gambling in the U.S., annually recognizes outstanding contributions to the field of gambling studies with theNCRG Scientific Achievement Award. This year’s award will be presented during theNCRG Conference on Gambling and Addictionin Las Vegas, October 2-4, 2011. The deadline for nominations is August 1, 2011.

Guidelines for Submitting a Nomination

The nomination package must include the following:

Letter of recommendation:A detailed letter of recommendation describing the worthiness of the nominee, specifying his or her contribution to the field of gambling studies, or the significance of the publication nominated.

Curriculum vitae (CV):For individual nominees, include an up-to-date CV. For research investigators, include a comprehensive bibliography of the nominee’s publications.

Publications:For research investigators, submit no more than five scientific publications representative of the nominee’s work. In the case of a nomination of a publication, include a copy of the published version of the article. The publication must have been published in the same year as or the year prior to the nomination.

Nominators must submit nomination materials in PDF format to Christine Reilly, senior research director, NCRG (creilly@ncrg.org) by August 1, 2011. The selection committee, composed of distinguished scientists in the addictions field, will select one recipient for the 2011 Scientific Achievement Award. For more information and a list of past award recipients, please visit the NCRG’s Scientific Achievement Awardwebsite.

Do you have questions or comments about the NCRG Scientific Achievement Awards or the 12thannual NCRG Conference on Gambling and Addiction? Please let us know in the comments below!

Nominations for the NCRG Scientific Achievement Award may include:

• Research investigators at any stage in their career whose research has made significant contributions to the knowledge base about gambling disorders.

• Educators who have successfully mentored young investigators in the field or have excelled at promoting public awareness and education about gambling disorders and responsible gaming.

• A recent publication in a scientific, peer-reviewed journal that represents seminal work in the field.

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The American Psychiatric Association (APA) has proposed new criteria for a diagnosis of pathological gambling (PG) in the next edition of theDiagnostic and Statistical Manual of Mental Disorders, slated for publication in 2013. As reported inIssues and Insightsand discussed at the 2010 NCRG Conference on Gambling and Addiction, the proposed revisions included moving PG from the impulse control category into a new classification, “addiction and related disorders.” It also proposes dropping illegal acts from the 10 criteria and possibly reducing the number of criteria needed for a diagnosis from five to four. A new review article by Howard J. Shaffer and Ryan Martin in the 2011Annual Review of Clinical Psychology(Shaffer & Martin, 2011) provides a critical review of these recommendations.

Currently, the DSM-IV-TR defines PG as a “… persistent and recurrent maladaptive gambling behavior … that disrupts personal, family or vocational pursuits” (American Psychiatric Association, 2000, p. 671).

Individuals who concurrently experience five or more of the following 10 criteria meet the diagnostic threshold for PG (American Psychiatric Association, 2000):

1. Preoccupation with gambling
2. Needing to gamble with increasing amounts of money in order to achieve the desired excitement
3. Repeated unsuccessful efforts to control, cut back, or stop gambling
4. Restless or irritable when attempting to cut down or stop gambling
5. Gambling as a way of escaping from problems
6. After losing money gambling, often returning another day to get even (“chasing” one’s losses)
7. Lying to family members, a therapist, or others to conceal the extent of involvement with gambling
8. Committing illegal acts such as forgery, fraud, theft, or embezzlement to finance gambling
9. Jeopardizing or losing a significant relationship, job, or educational or career opportunity because of gambling
10. Relying on others to provide money to relieve a desperate financial situation caused by gambling

In their review, Shaffer and Martin point out that the rationale for eliminating “committing illegal acts” as a symptom for the diagnosis could be used to eliminate other criteria as well. The DSM-5 Task Force argued that research has shown that this criterion has little to no effect on the prevalence of the disorder or diagnosis in the aggregate. However, Shaffer and Martin point out that the criterion of “jeopardizing relationships, work, or education” appears only at high severity levels of PG, and that preoccupation and chasing losses have such high prevalence among both non-PGs and PGs that these criteria alone have little diagnostic value under the current system (Shaffer & Martin, 2011).

The effect of eliminating illegal acts, they argue, will serve to only reduce the diversity of people who meet diagnostic criteria for PG. Lowering the threshold from five out of 10 symptoms to four out of nine symptoms will have a similar effect of reducing diversity because of the fewer number of combinations that can occur with diagnostic criteria (Shaffer & Martin, 2011).

Shaffer and Martin agree with the DSM-5 task force that there is a large body of evidence for the commonalities between PG and substance use disorders. This evidence provides the rationale for the task force’s recommendation to move PG into the new category of addiction and related disorders. Although the task force concluded that there was insufficient empirical evidence to warrant including behavioral disorders other than PG at this time, the creation of such a classification leaves the door open for Internet addiction and other non-substance-based disorders. Shaffer and Martin foresee a potential problem in the DSM ending up with a laundry list of behavioral disorders defined by their objects; e.g., gambling, the Internet, and sex to name several. In their view, such a list only reinforces the incorrect belief that things are addictive.

To avoid this problem, Shaffer and Martin propose the addiction as syndrome model as an organizing principle (Shaffer, LaPlante, et al., 2004). The syndrome model “postulates that there are shared neurobiological, psychological, and social risk factors that influence the development and maintenance of different manifestations of addiction. These risk factors are similar for both substance-based (e.g., cocaine dependency) and activity-based (e.g., disordered gambling) expressions of addiction” (Shaffer & Martin, 2011, p. 488). The authors maintain that conceptualizing “addiction this way avoids the incorrect view that the object causes the addiction and shifts the diagnostic focus toward patient needs” (Shaffer & Martin, p. 496).

These proposed changes to the DSM-5 will have a significant impact on researchers and treatment professionals alike. What do you think of the DSM-5 recommendations? Share your comments below.

References

American Psychiatric Association. (2000).Diagnostic and Statistical Manual of Mental Disorders., Fourth Edition, Text Revision. Washington, DC: American Psychiatric Association.

American Psychiatric Association (2010). 312.31 Pathological gambling. In Proposed Draft Revisions to DSM Disorders and Criteria. Arlington, VA: American Psychiatric Association.

Shaffer, H. J., LaPlante, D. A., LaBrie, R. A., Kidman, R. C., Donato, A. N., & Stanton, M. V. (2004). Toward a syndrome model of addiction: Multiple expressions, common etiology.Harvard Review of Psychiatry, 12, 367-374.

Shaffer, H. J., & Martin, R. (2011). Disordered gambling: etiology, trajectory, and clinical considerations.Annual Review of Clinical Psychology, 7, 483-510.

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If you have been following the Gambling Disorders 360˚ blog, you have heard about the NCRG’s many accomplishments in 2010. To highlight our successful year and look forward to the NCRG’s 2011 initiatives, we released theNCRG’s 2010 Annual Reportonline this week. We also began some of the 2011 social media initiatives as the NCRG officially launched its Twitter account,@theNCRG!

2010 was an exceptional year for the NCRG. We conducted successful events, from the informative Road Tour in Cleveland, Ohio to the annual conference in Las Vegas, Nev. We enhanced our social media presence by creating this blog and using it as a platform to discuss the finest peer-reviewed research and enhance the awareness of pathological gambling and responsible gaming among new audiences. The NCRG built upon the 2009 recommendations of the Task Force on College Gambling Policies to developCollegeGambling.org, a first-of-its-kind resource to address gambling and gambling related harms on college campuses. You can read the full annual report by clickinghere.

On the heels of the annual report, we would like to give you a preview of what is to come in 2011:

– The12thAnnual NCRG Conference on Gambling and Addictionwill be held on October 2-4 at the Las Vegas Sands and Convention Center, co-locating with Global Gaming Expo to continue providing valuable information about gambling disorders to a wider audience.

– TheNCRG Webinar Seriesis increasing the number of sessions and engaging in an exciting partnership with NAADAC, the Association for Addiction Professionals.

– We announced that the NCRG will allocate more than $700,000 for research grants in 2011 – nearly twice the amount funded in 2010.

– We will build upon the success of the Road Tour by hosting additional workshops for problem gambling treatment providers in various cities across the U.S.

– The NCRG will also enhance its online presence through new traditional and social media avenues.

This week, the NCRG took one more step to advance research, education and awareness online about pathological and youth gambling. The NCRG is pleased to announce that it is now on Twitter. If you are on the social network, follow@theNCRGor look for our updates onwww.twitter.com/theNCRG. We look forward to connecting with you on Twitter with up-to-date information on research on pathological and youth gambling, videos about the NCRG’s work, program and conference updates, and resources that help you translate research findings into real-world applications.

Connect with us through the networks below:

@theNCRG on Twitter

http://www.twitter.com/theNCRG

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We welcome your feedback on what information you want to see on Gambling Disorders 360˚ or any of our social networks. Please leave a comment in the section below!

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TheNational Center for Responsible Gaming(NCRG) presented the first installment of the 2011NCRG Webinar Seriesto more than 250 participants in March – one of the highest attended sessions for the NCRG. Led by Dr. Jon Grant, M.D., the webinar was titled “Gambling Disorders: What Addiction Professionals Need To Know” and cosponsored byNAADAC, the Association for Addiction Professionals. Visit theNCRG websitefor an archived version of the presentation.

Dr. Grant, a board-certified psychiatrist and principal investigator of the NCRG Center for Excellence in Gambling Research at the University of Minnesota, presented what he described as a “crash course” on gambling disorders for an audience that included many health care providers who specialize in drug and alcohol counseling. Dr. Grant discussed the nature and prevalence of gambling disorders (GD), vulnerable populations, comorbidity of GD and other mental health conditions, similarities between GD and other substance use disorders, and screening and diagnosis of GD as well as treatment options.

During his discussion of treatment options for gambling disorders Dr. Grant emphasized the variety of techniques that are currently being used to treat GD. Among these are several that are well-known to counselors and therapists, such as casino self-exclusion programs, psychotherapy, cognitive behavioral therapy, and motivational interviewing.

Dr. Grant also discussed less well-known techniques such as cue exposure therapy (CE). This therapy is based on theories of classical conditioning that hold that a person can learn to control cravings to gamble by being repeatedly exposed to situational cues in a therapeutic setting and learning to monitor and control their emotional and mental responses to each cue. CE therapy uses pictures and audio and video media related to gambling situations to trigger urges to gamble in clients, and teaches clients how to respond to these feelings.

If you missed the live presentation, you can access it and other past sessions free of charge in theWebinar Archivessection of theNCRG website. If you attended the NCRG Webinar in March, we would love to hear your feedback to improve future sessions. As always, we welcome your thoughts and questions, including suggestions for webinar topics, in the Comments section below.

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The application deadline for the NCRG’sSeed Grantsis quickly approaching – May 2, 2011. Make sure you download theannouncementandapplication formto apply today!

The Seed Grants program provides up to $25,000 to support small research projects that can be completed in one year. Seed Grant projects can include pilot and feasibility studies, secondary analysis of existing data, small, self-contained research projects and development of research methodology or new research technology. The Seed Grant is one of five types of the NCRG grants designed to increase the number of researchers in the field and encourage new investigators to explore gambling disorders research. The NCRG will award more than $700,000 in grant funding in 2011 – nearly twice the amount funded in 2010.

The NCRG expects to award three Seed Grants in 2011, so make sure to complete your applications and apply by May 2! For more information on the application process, please see the Seed Grantannouncementand download anapplication form.You can also find examples of previously funded studies on ourFunded Project Grantspage.

Questions or comments? You can leave them in the Comments section below or contact Christine Reilly, Senior Research Director, atcreilly@ncrg.org.

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Have you ever been screened for a health problem? The answer is probably yes if you’ve ever been questioned by your doctor about symptoms or responded to a telephone survey about health. There are numerous screening instruments used by clinicians to determine if a client has a gambling problem, and some often appear in general population surveys to research the prevalence of the disorder. The Division of Addictions at Cambridge Health Alliance, a teaching affiliate of Harvard Medical School, recently released the Brief Biosocial Gambling Screen (BBGS) to help people decide on their own whether to seek a formal evaluation of their gambling behavior. Development of the screen was funded by the NCRG.

The Division on Addictions at Cambridge Health Alliance launched the BBGS on itswebsite. This 3-item survey is based on the American Psychiatric Association’s Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for pathological gambling. The BBGS asks:

o During the past 12 months, have you become restless, irritable or anxious when trying to stop/cut down on gambling?

o During the past 12 months, have you tried to keep your family or friends from knowing how much you gambled?

o During the past 12 months, did you have such financial trouble as a result of your gambling that you had to get help with living expenses from family, friends or welfare?

A “yes” answer to any of the questions means the person is at risk for developing a gambling problem. A confidential, personalized message is provided to help guide the person to consider seeking further evaluation.

The development of the BBGS is described in the scientific paper, “Optimizing DSM-IV-TR Classification Accuracy: A Brief Biosocial Screen for Detecting Current Gambling Disorders Among Gamblers in the General Household Population,” published in theCanadian Journal of Psychiatrylast year (Gebauer et al., 2010). The authors derived the three questions from the results of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC) a survey of 43,093 households which has yielded the largest sample of pathological gamblers. Their objective was to develop a screening instrument that would correctly identify the largest proportion of current pathological gamblers and exclude non-pathological gamblers (i.e., reduce the number of false positives). Another consideration was the length of the screen. A concise survey is easy to use in a clinical setting or for a self-assessment and can be easily incorporated into a general survey.

Out of the 10 possible criteria listed in the DSM-IV , the authors’ analysis found that the top three criteria for identifying pathological gambling patterns and avoiding false positives were withdrawal, lying about one’s gambling and borrowing money to gamble. The resulting BBGS questions focus on these criteria. A copy of this paper is available for download from the Division on Addictionswebsite.

What do you think about the BBGS and other gambling screens? Please let us know in the Comments section below. The NCRG always welcomes your feedback.

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Why do so many people relapse when they are trying to stop gambling? It has been estimated that 50 to 75 percent of gamblers resume gambling after attempting to quit (N. M. Petry et al., 2006), but what are the thoughts, feelings and situations that precede these events? Researchers who study alcohol and drug abuse – disorders with similarly high rates of relapse – have developed a questionnaire designed to answer these questions for their audiences. A recent study published in the journalExperimental and Clinical Psychopharmacologyattempts to validate this same type of questionnaire for people with gambling disorders (Nancy M Petry, Rash, & Blanco, 2010). The new study attempts to extend and validate Petry’s previous work adapting the Inventory of Drinking Situations for gambling situations (called the Inventory of Gambling Situations, IGS).

The researchers gave the IGS to 283 people seeking treatment for alcohol and drug abuse who were also identified as problem or pathological gamblers. The IGS asked respondents how likely they were to gamble, on a 1 to 4 scale, in response to each of 47 different situations. The situations described the following types of scenarios:

– Emotional situations: “When other people treated me unfairly”

– Physical conditions: “When I would have trouble sleeping”

– Thought cues:“When I would start thinking about all the money I owe”

The researchers used statistical analysis to group similar questions together and to find out how much of the variance in gambling behavior was explained by each group of questions. The first group contained questions about negative emotions (e.g. “When I felt tense or nervous”) and explained 24.6 percent of the variation. The second group contained questions about positive emotions (e.g. “When I would be relaxed and wanted to have a good time”) and explained 15.2 percent of the variance in gambling behavior. The third group contained questions about gambling cues (e.g. “When I would see an advertisement about gambling”), and explained 9.5 percent of the variance. The final group contained questions about social situations (e.g. “When I was with friends and they were gambling”), and explained 8.3 percent of the variance.

All together, the IGS accounted for 57.6 percent of the variance in gambling behaviors found in the sample. This kind of information can be used by therapists to help clients identify what feelings and situations can lead to relapse. It is also possible that gamblers who are having problems, but have not yet progressed to a clinical gambling disorder, may be able to avoid more serious gambling problems by being aware of the feelings and situations that can trigger gambling behavior.

More information about the article is available on the website of the journalExperimental and Clinical Psychopharmacology. Do you have thoughts or questions about prevention and treatment of gambling disorders? Tell us in the Comments section below.

References

Petry, N. M., Ammerman, Y., Bohl, J., Doersch, A., Gay, H., Kadden, R., Molina, C., et al. (2006). Cognitive-behavioral therapy for pathological gamblers.Journal of Consulting and Clinical Psychology,74(3), 555-67. doi:2006-08433-015 [pii] 10.1037/0022-006X.74.3.555

Petry, N. M., Rash, C. J., & Blanco, C. (2010). The Inventory of Gambling Situations in problem and pathological gamblers seeking alcohol and drug abuse treatment.Experimental and Clinical Psychopharmacology,18(6), 530-538. doi:10.1037/a0021718

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The relationship between the brain chemical dopamine and disordered gambling has been well-established over the past several years (we discussed this relationship in the context of Parkinson’s Disease inthe July 2010Issues and Insights). Dopamine is associated with the reward system of the brain, which affects feelings of enjoyment and behavior reinforcement. It and other brain chemicals are, by their very nature, difficult to observe and thus difficult to translate into preventive applications. To bridge the gap between brain chemistry and disordered behavior, researchers can link the two with quantifiable emotions like excitement. The most recent edition ofThe WAGER(Worldwide Addiction Gambling Education Report) reviews a study that looks at those factors as they relate to pathological gambling.

The 2010 study, featured inThe WAGER – Vol. 16(3), examined the amount of dopamine released in the brain, excitement levels and gambling task performance in samples of people with pathological gambling (PG) and healthy controls (HC) (Linnet, Møller, Peterson, Gjedde, & Doudet, 2011). Researchers monitored the dopamine levels of 18 PGs and 16 HCs at baseline and while they completed a gambling task. The participants also reported their feelings of excitement during the task. The researchers found that PGs whose brains released more dopamine reported higher levels of excitement. Additionally, differences in dopamine release from non-gambling to gambling conditions were significantly correlated with changes in excitement level. The authors suggest that dopamine release may be doubly problematic, by reinforcing gambling behaviors and also promoting risky decision-making.

These findings further previous research which suggests that feelings of excitement while gambling reinforce unhealthy behaviors for some people with PG. This subset of people with PG crave feelings of excitement more than recreational gamblers or other people with PG, and may find gambling especially rewarding because of this (Vachon & Bagby, 2009).

For the full review or to access online reviews of research on other addictive disorders, visitThe BASIS (Brief Addiction Science Information Source).
As always, we welcome thoughts and questions in the comments section below.

References

Linnet, J., Møller, A., Peterson, E., Gjedde, A., & Doudet, D. (2011). Dopamine release in ventral striatum during Iowa Gambling Task performance is associated with increased excitement levels in pathological gambling.Addiction,106(2), 383-390. doi:10.1111/j.1360-0443.2010.03126.x

Vachon, D. D., & Bagby, R. M. (2009). Pathological gambling subtypes.Psychological Assessment,21(4), 608-615. doi:10.1037/a0016846

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Why do some children start gambling at a young age while others do not? Theorists have suggested that the answer to this question is some combination of individual traits and environmental factors, both nature and nurture, but it is not yet understood which traits and factors have more of an influence on behavior. To address this question, researchers must examine the same children over a length of time (in what is called a longitudinal study) in order to see what traits in a younger child predict gambling behavior as the child ages. A recent study of Canadian children published in the journalPsychology of Addictive Behaviorstook just this approach (Vitaro & Wanner, 2011). The researchers gathered information about 1,125 children and their families between the ages of six and eight, and then measured their gambling behavior at the age of 10. The findings suggest that preventing gambling in children will require a multifaceted approach that addresses all of the potential risk factors involved.

The researchers measured several variables in the children, including their teacher’s impressions of child sensitivity to reward and punishment, parent gambling behavior and demographic factors. Low sensitivity to punishment, which is controlled in the brain by serotonin levels in what is called the behavioral inhibition system (BIS), is manifested in low inhibition and lack of regard for consequences. High sensitivity to reward, which is controlled in the brain by dopamine levels in what is called the behavioral activation system (BAS), is demonstrated in impulsive behavior. These two systems are biologically distinct from each other and vary from person to person.

The researchers were especially interested in how the BIS and BAS interacted with each other, and with the gambling behavior of the parents, to affect gambling in children. One hypothesis is that the systems affect each other. For example, a child who is very sensitive to rewards might be more likely to gamble, but if that same child were also very sensitive to punishment the aversion to punishment might override the desire for rewards and keep him/her from gambling. Another hypothesis is that the systems do not interact at all, and each exerts a separate impact on the individual child.

The researchers’ findings support the second hypothesis. Both BIS and BAS, as well as parental gambling, independently affected whether or not children gambled at the age of 10. That is, the children who were more likely to gamble at age 10 had teachers who thought they were more sensitive to rewards, less sensitive to punishment, or whose parents gambled. However, whether parents suffered from disordered gambling was not a factor. This may be because young children are not aware of their parent’s gambling problems, or because too few family members had gambling problems to achieve statistical significance in this study. While this study lays the groundwork for discussions of what causes youth gambling, more research is needed to further unravel the relationship between genetics, environment and childhood gambling.

More information on the article is available on the website of the journalPsychology of Addictive Behaviors. Do you have thoughts or questions about gamblingamong young children? Tell us in the Comments section below.

References

Vitaro, F., & Wanner, B. (2011). Predicting early gambling in children.Psychology of Addictive Behaviors. doi:10.1037/a0021109

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Measuring addictive behaviors accurately is very difficult. Among the many complications are recruiting subjects, relying on their memory and self-report and quantifying the difference between pathological actions and actions that are merely unusual or uncommon. (Jerome Wakefield, Ph.D.,discussed this topic in detailat the NCRG conference 2010.) One particularly difficult aspect of studying addiction is the diagnostic screening instrument (when scored, the instrument shows whether or not a person should be diagnosed with a particular disorder). Diagnostic screens of all kinds pose the problem of advancement versus consistency: It is always possible to make a newer and better instrument, but a new instrument means that studies conducted with the older one cannot be directly compared to studies conducted with the new instrument. This tension dictates that new instruments must be shown as better along several lines to make them worth implementing. Two researchers at the forefront of this discussion for gambling disorders are Erica Fortune and Adam Goodie, Ph.D., at the University of Georgia. Fortune and Goodie recently published a study, partly funded by a grant from the NCRG to Dr. Goodie, that compares the performance of two diagnostic screens in a population of college students (Fortune & Goodie, 2010).

The researchers compared two gambling screens, the South Oaks Gambling Screen (SOGS) (Lesieur & Blume, 1987) and the Diagnostic Interview for Gambling Severity-S (DIGS-S) (Winters & Stinchfield, 1996). The SOGS was published in 1987 and is the most-used screening instrument for gambling disorders. (Ina recent blogreviewing the 10 most cited gambling research papers of all time, the SOGS paper was number one). The DIGS-S is a more recent screen with questions that mirror the diagnostic criteria for pathological gambling in the American Psychiatric Association’sDiagnostic and Statistical Manual of Mental Disorders(American Psychiatric Association, 1994). The DIGS-S was derived from the original Diagnostic Interview for Gambling Severity (DIGS) that was designed for clinicians to diagnose patients in clinical settings.

To test the two instruments, the researchers recruited 72 undergraduate students who self-identified as frequent gamblers. The participants were given both instruments three times over the course of two months. This allowed the participants’ scores on each screen to be compared to each other and to their previous score on the same scale (a common method for validating diagnostic instruments). The results showed that while both screens performed well, the DIGS-S was more reliable over the three administrations than the SOGS. Coupling this finding with the ease with which the DIGS-S is given to college students via computer, the DIGS-S appears to be a valid alternative to the SOGS for studying disordered gambling in college populations.

More information on the article is available on the website of theJournal of Gambling Studies. Do you have thoughts or questions about problem gambling research or diagnosing gambling problems? Are you a college student and are looking for more information? Please visitwww.CollegeGambling.orgor start a conversation in the Comments section below.

References

American Psychiatric Association. (1994).DSM-IV: Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Association.

Fortune, E. E., & Goodie, A. S. (2010). Comparing the utility of a modified Diagnostic Interview for Gambling Severity (DIGS) with the South Oaks Gambling Screen (SOGS) as a research screen in college students.Journal of Gambling Studies / Co-Sponsored by the National Council on Problem Gambling and Institute for the Study of Gambling and Commercial Gaming,26(4), 639-644. doi:10.1007/s10899-010-9189-x

Lesieur, H. R., & Blume, S. B. (1987). The South Oaks Gambling Screen (SOGS): A new instrument for the identification of pathological gamblers.American Journal of Psychiatry,144(9), 1184-8.

Winters, K. C., & Stinchfield, R. D. (1996).Diagnostic Interview for Gambling severtiy (DIGS). Minneapolis: University of Minnesota Medical School.

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